The files in this folder contain a list of genetic variants and corresponding beta coefficients to construct the two coronary artery disease (CAD) polygenic risk scores (PRS) featured in the CARDIoGRAMplusC4D 1 Million Hearts project:

Aragam KG, Jiang T, Goel A et al (2022). Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants. Nature Genetics.

See Supplementary Tables 12 and 14 for details regarding the respective PRS.


## "FINAL_1MH_CAD_PRS_2015_LDpred.txt.gz" -- best-performing PRS derived from CARDIoGRAMplusC4D 1000G meta-analysis (Nikpay et al. Nature Genetics 2015)

## "FINAL_1MH_CAD_PRS_2022_LDpred.txt.gz" -- best-performing PRS derived from CARDIoGRAMplusC4D 1 Million Hearts meta-analysis


## CHR:POS:REF:ALT = coordinates based on hg19
## nt2 = effect allele. 
## ldpred_beta = LDpred-adjusted beta coefficient; weight used for PRS construction